Potentiated hypoglycemic action w/ NSAIDs & other highly protein bound drugs eg, salicylates, sulfonamides, chloramphenicol, coumarin derivatives, probenecid, MAOIs, & β-adrenergic blocking agents. Reduced hypoglycemic effect w/ thiazides & other diuretics, corticosteroids, phenothiazines, estrogens, OCs, nicotinic acid, sympathomimetics, thyroid hormones & INH.